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Anti-allergic effect of G7

G7 at various concentrations was studied to find out its efficacy in reducing histamine induced oedema, erythema and itching on skin.

Study findings

  • The erythema (wheal and flare reaction) as well as the itching response were completely absent at the test sites where G7 concentration was 0.7% and more.

The study findings confirm the efficacy of G7 as an anti-allergic drug.

G7 Capsules- a Promising Alternative for Management of Allergic Disorders.

  • Histamine and Cytokines like Interleukin (IL) 1α & IL 8 play a key role in inflammatory allergic disorders.
  • On sensitization, mast cells and basophils release Histamine and keratinocytes release IL 1α and IL 8.
  • Therefore, dose-dependent effect of G7 capsule on histamine, IL α and IL8 release was tested

Study findings

  • The release of histamine from the cultured mast cells lowered with increase in concentration of G7.
  • The release of IL1α was highly suppressed by G7 at 100 µg concentration.
  • G7 effectively suppressed the release of IL8 by the keratinocytes when irradiated by UV or induced by PMA.

From the above findings, it can be concluded that G7 be effective in management of allergic reactions in skin.

Mast cell degranulation effect of G7 Capsules

Effect of oral G7 capsules on mast cells inhibiting its degranulation and release of histamine and proteases (allergy-related complications) was studied in both in vitro and in vivo conditions.

Study findings

  • G7 significantly blocked the mast cell degranulation both in vivo and in vitro tests.

From the above finding, it can be concluded that G7 is very effective in the management of allergy-related complications.